A Novel Drug-Carrier Based on CMC/MATPP-PTX(CTP) and In Vitro Release

A novel drug-carrier for paclitaxel entrapment entitled CMC/MATPP-PTX(CTP) was developed starting from the synthesis of MATPP that was grafted to CMC when EDC/NHS was served as coupling agent. Fourier Infrared Spectrometer (FT-IR) and 1H Nuclear Magnetic Resonance (1H NMR) characterized their constituents and structures information. Laser particle size analyzer (LPSA) and Scanning electron microscope (SEM) measured their size distribution and observed their morphology. Results showed substitution rate of CMC is up to 0.229 when the CMC: MATPP (mole ratio) is 1:0.016. CTP represents different microscale in distinct ratio of H2O/Ethanol or H2O/Acetone aqueous solution. SEM revealed the CTP possess a mean 500 ± 40 nm sizes. PTX loading and encapsulation rates are 14.6% and 8.9% when the ratio of CMC/MATPP:PTX (mole ratio) is 1:2, respectively. The cumulative release of paclitaxel can reach up to 59.75% within 5 h.