螯合作用
共轭体系
体内
化学
组合化学
有机化学
生物
聚合物
生物技术
作者
Gábor Nagy,Dezső Szikra,György Trencsényi,Anikó Fekete,Ildikó Garai,Arianna Maria Giani,Roberto Negri,Norberto Masciocchi,Alessandro Maiocchi,Fulvio Uggeri,Imre Tóth,Silvio Aime,Giovanni B. Giovenzana,Zsolt Baranyai
标识
DOI:10.1002/anie.201611207
摘要
Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44 Sc(AAZTA)- chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
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