奇异变形杆菌
微生物学
佐剂
乳酸乳球菌
免疫系统
接种疫苗
重组DNA
医学
生物
免疫学
病毒学
细菌
乳酸
生物化学
基因
遗传学
金黄色葡萄球菌
作者
Jiayu Zhou,Kai Wei,C. Wang,Wenwen Dong,Ningning Ma,Lin Zhu,Liping Hu,He Huang,Rui‐Liang Zhu
出处
期刊:Allergologia et immunopathologia
[Codon Publications]
日期:2017-09-01
卷期号:45 (5): 496-505
被引量:6
标识
DOI:10.1016/j.aller.2017.04.005
摘要
Proteus mirabilis poses a critical burden on the breeding industry, but no efficient vaccine is available for animals. A recombinant Lactococcus lactis expressing the ompA of P. mirabilis was used to develop a vaccine. The mucosal and systemic immune responses of the recombinant vaccine were evaluated in mice after oral immunisation. The inhibition on P. mirabilis colonisation of vaccines was also determined. Moreover, Taishan Pinus massoniana pollen polysaccharides (TPPPS) were used as adjuvants to examine the immunomodulatory effects. The pure recombinant L. lactis vaccine significantly induced the production of specific IgA and IgG, IL-2, IL-4, IFN-γ, and T lymphocyte proliferation, and the immunised mice exhibited significant resistance to P. mirabilis colonisation. Notably, the TPPPS adjuvant vaccines induced higher levels of immune responses than the pure L. lactis. The L. lactis as a vaccine vehicle combined with TPPPS adjuvant provides a feasible method for preventing P. mirabilis infection.
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