壳核
心理学
注意缺陷多动障碍
功能磁共振成像
神经科学
功能连接
腹侧纹状体
伏隔核
纹状体
尾状核
多巴胺
精神科
作者
Daniel von Rhein,Marianne Oldehinkel,Christian F. Beckmann,Jaap Oosterlaan,Dirk J. Heslenfeld,Catharina A. Hartman,Pieter J. Hoekstra,Barbara Franke,Roshan Cools,Jan K. Buitelaar,Maarten Mennes
摘要
Background Task‐based and resting‐state functional Magnetic Resonance Imaging (fMRI) studies report attention‐deficit/hyperactivity disorder ( ADHD )‐related alterations in brain regions implicated in cortico‐striatal networks. We assessed whether ADHD is associated with changes in the brain's global cortico‐striatal functional architecture, or whether ADHD ‐related alterations are limited to local, intrastriatal functional connections. Methods We included a cohort of adolescents with ADHD ( N = 181) and healthy controls ( N = 140) and assessed functional connectivity of nucleus accumbens, caudate nucleus, anterior putamen, and posterior putamen. To assess global cortico‐striatal functional architecture we computed whole‐brain functional connectivity by including all regions of interest in one multivariate analysis. We assessed local striatal functional connectivity using partial correlations between the time series of the striatal regions. Results Diagnostic status did not influence global cortico‐striatal functional architecture. However, compared to controls, participants with ADHD exhibited significantly increased local functional connectivity between anterior and posterior putamen ( p = .0003; ADHD : z = .30, controls: z = .24). Results were not affected by medication use or comorbid oppositional defiant disorder and conduct disorder. Conclusions Our results do not support hypotheses that ADHD is associated with alterations in cortico‐striatal networks, but suggest changes in local striatal functional connectivity. We interpret our findings as aberrant development of local functional connectivity of the putamen, potentially leading to decreased functional segregation between anterior and posterior putamen in ADHD .
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