氟康唑
医学
侵袭性念珠菌病
低出生体重
两性霉素B
儿科
抗生素
肠内给药
广谱
重症监护医学
抗真菌
肠外营养
怀孕
生物
皮肤病科
微生物学
化学
组合化学
遗传学
作者
Shilpa G. Hundalani,Mohan Pammi
标识
DOI:10.1586/14787210.2013.811925
摘要
Invasive fungal infections due to Candida are the third most common late-onset infection in infants born with birth weight <1500 g. Invasive candidiasis in infants born with birth weight <1000 g is associated with a 30% mortality and with neurodevelopmental impairment in more than half the survivors. A high degree of suspicion and a thorough multisystem evaluation is necessary for diagnosis of invasive fungal infections and to detect complications or sequalae. Amphotericin B deoxycholate is the mainstay in the treatment of invasive fungal infections in newborns. Early initiation of enteral feeds with human milk, decreasing dependence on catheters and avoidance of antacids, steroids and broad-spectrum antibiotics are the recommended preventive measures. Fluconazole prophylaxis should be targeted towards neonates born with <1000 g in neonatal units where baseline rates of invasive candidiasis are more than 5%.
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