鼻咽癌
医学
放射治疗
破译
重症监护医学
肿瘤科
疾病
病理
内科学
生物信息学
生物
作者
Anne W.M. Lee,Brigette Ma,Wai Tong Ng,Anthony T.�C. Chan
标识
DOI:10.1200/jco.2015.60.9347
摘要
Nasopharyngeal carcinoma of the undifferentiated subtype is endemic to southern China, and patient prognosis has improved significantly over the past three decades because of advances in disease management, diagnostic imaging, radiotherapy technology, and broader application of systemic therapy. Despite the excellent local control with modern radiotherapy, distant failure remains a key challenge. Advances in molecular technology have helped to decipher the molecular pathogenesis of nasopharyngeal carcinoma as well as its etiologic association with the Epstein-Barr virus. This in turn has led to the discovery of novel biomarkers and drug targets, rendering this cancer site a current focus for new drug development. This article reviews and appraises the key literature on the current management of nasopharyngeal carcinoma and future directions in clinical research.
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