干细胞
癌症干细胞
造血
生物
癌症研究
人口
免疫学
细胞生物学
医学
环境卫生
作者
Brian J. P. Huntly,D. Gary Gilliland
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2005-04-01
卷期号:5 (4): 311-321
被引量:532
摘要
Many cancers seem to depend on a small population of 'cancer stem cells' for their continued growth and propagation. The leukaemia stem cell (LSC) was the first such cell to be described. The origins of these cells are controversial, and their biology - like that of their normal-tissue counterpart, the haematopoietic stem cell (HSC) - is still not fully elucidated. However, the LSC is likely to be the most crucial target in the treatment of leukaemias, and a thorough understanding of its biology - particularly of how the LSC differs from the HSC - might allow it to be selectively targeted, improving therapeutic outcome.
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