[Molecular mechanism and treatment strategy of colorectal cancer peritoneal metastasis].

Peritoneal metastatic colorectal cancer (pmCRC) is common and has been considered as the terminal stage. The theory of "seed and soil" and "oligometastasis" are the acknowledged hypotheses of pathogenesis of pmCRC. In recent years, the molecular mechanism related to pmCRC has been deeply researched. We realize that the formation of peritoneal metastasis, from detachment of cells from primary tumor to mesothelial adhesion and invasion, depends on the interplay of multiple molecules. Various components of tumor microenvironment also work as regulators in this process. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been widely used in clinical practice as an established treatment for pmCRC. Besides systemic chemotherapy, targeted and immunotherapeutic drugs are also increasingly used to improve prognosis. This article reviews the molecular mechanisms and treatment strategies related to pmCRC.腹膜是结直肠癌的常见转移部位，腹膜转移被认为是结直肠癌的晚期阶段。“种子-土壤”学说和“寡转移”学说是腹膜转移发生发展机制的主要假设。近年来，结直肠癌腹膜转移相关的机制研究逐渐深入，我们更加清晰地认识到腹膜转移灶的形成依赖于多种分子的协同作用，以完成肿瘤细胞脱离原发灶至定植于腹膜并形成转移灶的全过程，而肿瘤微环境的各组成部分也在其中发挥了重要的调控作用。在治疗方面，肿瘤细胞减灭术及腹腔热灌注化疗在临床上得到了更为广泛的应用。而随着分子机制研究的进展，除全身化疗外，靶向治疗和免疫治疗也越来越多地应用于腹膜转移的治疗中，有助于改善结直肠癌腹膜转移患者的预后。.