1Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, Zhejiang, China 2Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325035, Zhejiang, China Abbreviations: AFP, Alpha-fetoprotein; DCR, Disease control rate; ECOG, Eastern Cooperative Oncology Group; HCC, Hepatocellular carcinoma; ORR, Objective response rate; PVTT, Portal vein tumor thrombosis; Sin-Bev-RT, Sintilimab and Bevacizumab combined with Radiotherapy Correspondence Su Lihuang, Department of Respiratory Medicine The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325035, Zhejiang, China. Email: [email protected]