New avenues for cancer immunotherapy: Cell-mediated drug delivery systems

癌症免疫疗法 免疫疗法 药物输送 癌症 医学 药品 药理学 纳米技术 内科学 材料科学
作者
Qian Zhang,Adam Grippin,Man Sun,YuHui Ma,Betty Y.S. Kim,Zhaogang Yang,Wen G. Jiang,Zhaogang Yang
出处
期刊:Journal of Controlled Release [Elsevier]
卷期号:375: 712-732
标识
DOI:10.1016/j.jconrel.2024.09.037
摘要

Cancer research has become increasingly complex over the past few decades as knowledge of the heterogeneity of cancer cells, their proliferative ability, and their tumor microenvironments has become available. Although conventional therapies remain the most compelling option for cancer treatment to date, immunotherapy is a promising way to harness natural immune defenses to target and kill cancer cells. Cell-mediated drug delivery systems (CDDSs) have been an active line of research for enhancing the therapeutic efficacy and specificity of cancer immunotherapy. These systems can be tailored to different types of immune cells, allowing immune evasion and accumulation in the tumor microenvironment. By enabling the targeted delivery of therapeutic agents such as immune stimulants, cytokines, antibodies, and antigens, CDDSs have improved the survival of some patients with cancer. This review summarizes the research status of CDDSs, with a focus on their underlying mechanisms of action, biology, and clinical applications. We also discuss opportunities and challenges for implementation of CDDSs into mainstream cancer immunotherapy.
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