肝细胞癌
线粒体
材料科学
程序性细胞死亡
纳米颗粒
肝癌
免疫原性细胞死亡
癌症研究
细胞凋亡
纳米技术
生物物理学
生物
细胞生物学
生物化学
作者
Siyu Chen,Yiyang Sun,Yangla Xie,Yanpeng Liu,Haitao Hu,Chang Zhan Xie,Shengjun Xu,Z. G. Zhang,Jing Zhang,Youqing Shen,Xiao Xu,Nasha Qiu
标识
DOI：10.1021/acsami.4c13433
摘要
Hepatocellular carcinoma (HCC) is a highly malignant tumor that is resistant to chemotherapy and immunotherapy. Icaritin (ICT), a traditional Chinese medicine, has been reported as an immunoregulatory agent for treating advanced unresectable HCC. ICT induces mitophagy to cause immunogenic cell death (ICD); however, the poor bioavailability of ICT limits its therapeutic efficacy and clinical use. Therefore, this study aimed to assess the effect of using the poly(2-(
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