Electromagnetic (EM) pollution is becoming increasingly severe due to the explosive growth of various communication devices. EM protection materials are the key to solving EM pollution. MXenes, by virtue of larger specific surface area, numerous surface functional groups and excellent conductivity, are attracting increasing attention and showing competitive performance in EM protection. By constructing 3D MXene architectures, not only can the EM protection performance be significantly improved, but it can also meet the development needs of lightweight, miniaturization, and portability in the future. In this review, we summarized the methods for preparing 3D MXene architectures applied in the field of EM protection. Then, we comprehensively elaborate on the structure-property relationships of 3D MXene architectures and their applications in microwave absorption (MA) and electromagnetic interference (EMI) shielding. Finally, we discuss the challenges and opportunities in the development of 3D MXene architectures for EM protection.