血管生成
伤口愈合
血管内皮生长因子
化学
新生血管
去铁胺
药理学
炎症
治疗性血管生成
皮肤修复
慢性伤口
癌症研究
细胞生物学
医学
免疫学
生物化学
生物
血管内皮生长因子受体
作者
Fanjia Dai,Jiaying Zhang,Fengjiao Chen,Xianwu Chen,Chang Kyun Lee,Hongze Liang,Lingling Zhao,Hui Tan
标识
DOI:10.1002/advs.202408783
摘要
Abstract The repair of diabetic wound still encounters huge challenges, such as disordered inflammatory regulation and impaired neovascularization. Here, a pH/ROS/glucose responsive and photothermal hydrogel is developed for diabetic wound healing. The hydrogel is formed through cross‐linkage between phenylboronic acid‐modified carboxymethyl chitosan (CMCS‐PBA) and oxide dextran (OXD), utilizing Schiff base and phenylboronate ester bonds. Additionally, insulin‐like growth factor 1 C domain (IGF‐1C) and deferoxamine‐loaded polydopamine nanoparticles (D@P) are incorporated into the hydrogel. The hydrogel demonstrates sustained drug release, excellent photo thermal effect, prominent antioxidant, antibacterial and anti‐inflammatory activities, desirable mechanical and tissue adhesive properties, enhanced tube formation, and cell migration. Furthermore, the hydrogel combined with mild heat treatment can regulate chronic inflammation by promoting the transformation of macrophages from M1 phenotype to M2 phenotype and enhance angiogenesis by up‐regulating the expression levels of angiogenesis‐related factors such as hypoxia‐inducible factor‐1 alpha (HIF‐1α), vascular endothelial growth factor (VEGF), CD31, and α‐SMA, thus greatly accelerates the wound healing in streptozotocin (STZ)‐induced diabetic mice. Therefore, this multi‐responsive and multifunctional hydrogel holds potential as a therapeutic strategy for diabetic wounds.
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