视蛋白
光遗传学
遗传增强
眼科
医学
失明
基因
视网膜
生物
视紫红质
验光服务
遗传学
神经科学
作者
Adnan Dibas,Subrata Batabyal,Sang Hoon Kim,Michael Carlson,Samarendra Mohanty,Najam A. Sharif
出处
期刊：Journal of Ocular Pharmacology and Therapeutics
[Mary Ann Liebert]
日期：2024-10-23
标识
DOI：10.1089/jop.2024.0084
摘要
Leber congenital amaurosis (LCA) is a sight-threatening inherited retinal disorder (IRD) caused by numerous genetic mutations. Multi-characteristic opsin (MCO)-based optogenetic therapy allows the recruitment of residual cells of the retina in LCA for alternative vision transduction while being mutation-agnostic. Using
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