Evaluating the risk of venous thromboembolism in transfeminine and gender diverse people: A retrospective analysis.

医学 静脉血栓栓塞 激素疗法 糖尿病 优势比 静脉血栓形成 内科学 血栓形成 癌症 乳腺癌 内分泌学
作者
Daniel J. Slack,Nithya Krishnamurthy,Derek Chen,Felix G. Contreras-Castro,Joshua D. Safer
出处
期刊:Endocrine Practice [Elsevier BV]
标识
DOI:10.1016/j.eprac.2024.08.014
摘要

Teaching Points:•Venous thromboembolism (VTE) is an uncommon event in transgender and gender-diverse individuals, with a prevalence that may be even lower than previously believed.•VTE is associated with older age, potential surrogate measures for social determinants of health, and cardiometabolic comorbid conditions, highlighting the concept that one's risk of VTE is driven by a complex multitude of medical and non-medical factors, often occurring in tandem.•Feminizing gender-affirming hormone therapy using exogenous estrogen may not be independently associated with an increased risk of VTE but should be an indicator to look for other factors that may heighten one's risk.AbstractObjectiveThe risk of venous thromboembolism (VTE) with feminizing gender-affirming hormone therapy (GAHT) is an area of concern. This analysis aimed to assess whether GAHT and other potential risk factors are associated with VTE in transfeminine and gender diverse (TGD) individuals.MethodsWe conducted a chart review of 2,126 TGD adults receiving care within a large urban health system. The primary outcomes were the prevalence of VTE and odds ratios for the association of VTE with insurer, use of estrogen, and select comorbidities.ResultsA history of VTE was documented in 0.8% of the cohort. Those with a history of VTE were older (p<.001), more often self-identified as Hispanic or Black compared to white or Asian (p<.05) and were more likely to have Medicaid or Medicare (p<.01) when compared to those without a history of VTE. The prevalence of hyperlipidemia (p<.001), diabetes mellitus (p<.05), and hypercoagulable conditions (p<.001) were all greater in the +VTE group. Hyperlipidemia (p<.001), diabetes mellitus (p<.05), and insurer (p<.05) were associated with increased odds of VTE in univariate analyses. None of the exposure variables analyzed were associated with VTE when controlling for age, race, and the number of comorbidities.ConclusionsThe prevalence of VTE in our cohort was lower than previously observed. VTE was not associated with any one risk factor, including estrogen use, when controlling for age, race, and the number of comorbidities. Those of advanced age and those with multiple cardiometabolic comorbidities may benefit from increased surveillance and mitigation of modifiable risk factors.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
打打应助高兴松鼠采纳,获得10
刚刚
喜悦幻灵完成签到 ,获得积分10
1秒前
1秒前
gogoyoco发布了新的文献求助10
2秒前
xn201120发布了新的文献求助10
2秒前
英俊的铭应助西门访天采纳,获得30
3秒前
H2CO3发布了新的文献求助10
5秒前
5秒前
6秒前
6秒前
幸福大白发布了新的文献求助10
6秒前
爆米花应助Leoniko采纳,获得10
6秒前
6秒前
6秒前
李星完成签到,获得积分20
6秒前
7秒前
8秒前
8秒前
9秒前
赘婿应助YJ888采纳,获得10
10秒前
surong发布了新的文献求助10
11秒前
Shelby发布了新的文献求助10
11秒前
dyc238100发布了新的文献求助10
12秒前
树精发布了新的文献求助10
12秒前
liii发布了新的文献求助10
12秒前
12秒前
火柴盒完成签到,获得积分10
13秒前
如此这般发布了新的文献求助10
13秒前
14秒前
14秒前
15秒前
幸福大白发布了新的文献求助30
16秒前
Akitten关注了科研通微信公众号
16秒前
16秒前
闾丘剑封发布了新的文献求助10
18秒前
天天快乐应助Shelby采纳,获得10
18秒前
18秒前
华仔应助xn201120采纳,获得10
19秒前
木子李发布了新的文献求助10
19秒前
搬砖小土妞完成签到,获得积分20
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989510
求助须知:如何正确求助?哪些是违规求助? 3531756
关于积分的说明 11254536
捐赠科研通 3270255
什么是DOI,文献DOI怎么找? 1804947
邀请新用户注册赠送积分活动 882113
科研通“疑难数据库(出版商)”最低求助积分说明 809176