生物相容性
磁小体
材料科学
生物矿化
趋磁细菌
纳米花
核化学
抗菌活性
傅里叶变换红外光谱
表面改性
膜
化学工程
扫描电子显微镜
纳米技术
细菌
化学
磁铁矿
生物化学
生物
纳米结构
复合材料
冶金
工程类
遗传学
作者
Qi Jing,Zewei Wang,Xin Wen,Wei Tan,Yahong Yuan,Tianli Yue
标识
DOI:10.1021/acsami.3c08483
摘要
The natural biofilm on magnetosomes obtained from the biomineralization of magnetotactic bacteria, which replaced a complex chemical modification process on the surface of Fe3O4, can be used as the organic component and copper(II) ions as the inorganic component to form organic-inorganic nanoflowers in phosphate systems. Characterization by scanning electron microscopy, Fourier transform infrared spectroscopy, and vibrating-sample magnetometry proved that magnetic nanoflowers loaded with silver ions (Ag/MN-Cu×NFs) were successfully fabricated. In vitro antibacterial experiments demonstrated that Ag/MN-Cu×NFs displayed strong antibacterial effects against Escherichia coli and Staphylococcus aureus, with minimum inhibitory concentrations of 10 and 80 μg/mL, respectively. Ag/MN-Cu×NFs, which possessed good biocompatibility as confirmed by cytotoxicity and hemolysis tests, were able to promote wound healing in the face of bacterial infection in vivo without causing toxicity to major organs. Therefore, magnetosomes as a natural carrier have great application potential in the synthesis of multifunctional magnetosomes by direct hybridization with a target substance.
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