All-cause and specific mortality in patients with gout: A systematic review and meta-analysis

医学 痛风 荟萃分析 漏斗图 内科学 出版偏见 子群分析 科克伦图书馆 死亡率 队列研究 入射(几何) 相对风险 死亡风险 队列 置信区间 物理 光学
作者
Wei Wang,Xuanlin Li,Hongli Wang,Min Chen,Chengping Wen,Lin Huang,Mingqian Zhou
出处
期刊:Seminars in Arthritis and Rheumatism [Elsevier BV]
卷期号:63: 152273-152273 被引量:5
标识
DOI:10.1016/j.semarthrit.2023.152273
摘要

This meta-analysis aims to examine the general mortality risk and specific mortality risk of gout, as the incidence of the condition is on the rise but information on mortality rates remains uncertain. The researchers conducted a search of published cohort studies on gout and mortality using Medical subject headings and keywords in PubMed, EMBASE, and Cochrane Library databases from inception to September 2022. The quality of study was evaluated using the NOS scale. Statistical analysis was performed using STATA software (version 16.0). Publication bias was assessed using funnel plots and Egger's test. This meta-analysis included 11 cohort studies (2010-2022), covering 14,854,490 people with a follow-up time of 1.66-16 years. The pooled analysis shows increased risk of overall mortality [HR=1.23, 95% CI (1.13-1.35), I2=96.4%, P<0.001], cardiovascular mortality [HR=1.29, 95% CI (1.13-1.48), I2=98.5%, P<0.001], infection mortality [HR=1.24, 95% CI (1.04-1.47), I2=88.5%, P=0.019], and digestive system disease mortality [HR=1.42, 95% CI (1.13-1.80), I2=91.7%, P=0.003] in gout. Sensitivity and subgroup analysis support the findings, and publication bias was not evident. The findings from our meta-analysis indicate that gout is associated with an increased risk of all-cause mortality, as well as mortality related to cardiovascular disease, infections, and digestive system diseases. This has important implications for clinical practice, nursing care of patients with gout, and guidance on lifestyle modifications to prevent adverse outcomes such as cardiovascular events, infections, and digestive disorders.
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