A fast-expanding sector of agriculture worldwide is aquaculture. The production of fish internationally accounts for around 44 % of the total. Even though the aquaculture environment presents several difficulties, the current development in aquaculture production comes with an increase in infectious diseases, which significantly impacts the production, profitability, and sustainability of the worldwide aquaculture business. Many infectious agents, such as bacteria, viruses, fungi and parasites are causative agents for fish infections. Most infectious diseases found in all types of fish like marine water, freshwater and ornamental fishes are caused by bacteria, with many of them serving as secondary opportunistic invaders that attack sick animals by affecting their natural host immunity. To overcome this, addressing health issues based on methods that have been scientifically verified and advised will help lessen the effects of fish disease. This review aims to highlight some of the common microbial-infecting agents of fish in all types of aquatic systems and their effective methods for preventing infections in aquaculture.