Transition-metal-free radical phosphorylation/cyclization of unactivated alkenes: Access to phosphine-containing quinazolinones

A new cascade radical addition/cyclization of unactivated alkenes and phosphine oxides has been developed. A wide variety of bioactive phosphine-containing quinazolinones were obtained in up to 91% yield for 34 examples under transition-metal-free conditions. This cascade protocol represents an environmentally friendly and efficient way to build phosphine-containing quinazolinones in excellent yields under mild conditions with a broad substrate scope and high atomic economy.