A novel synthetic peptide analog enhanced antibacterial activity of the frog-derived skin peptide wuchuanin-A1

抗菌活性 抗菌剂 抗菌肽 抗菌肽 抗菌剂 抗真菌 肽序列 化学 细菌 组合化学 生物化学 生物 微生物学 抗生素 基因 遗传学
作者
Rizki Amalia Putri,Muhammad Saifur Rohman,Respati Tri Swasono,Tri Joko Raharjo
出处
期刊:Journal of Biomolecular Structure & Dynamics [Informa]
卷期号:: 1-11
标识
DOI:10.1080/07391102.2023.2281633
摘要

In recent years, there has been a growing focus on the development of novel antibacterial compounds for clinical applications, such as antimicrobial peptide (AMP). Among the developed AMP, wuchuanin-A1, a coil-shaped bioactive peptide derived from Odorrana wuchuanensis frog skin, has been reported to exhibit antibacterial, antifungal, and antioxidant activity, but there are limited studies on its potential as an antibacterial agent. Therefore, this study aims to molecularly modify the sequence of wuchuanin-A1 to enhance its antibacterial properties. The interaction of both the native and analog peptide with bacterial inner membranes was initially assessed using computational methods. Specific amino acid substitutions were then used to enhance the modified peptide’s antibacterial efficacy, followed by several preliminary tests to evaluate its activity. This study bridges the gap in exploring the potential of wuchuanin-A1 for antibacterial purposes, providing insights into the design of effective antimicrobial agents.
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