Genetic Variations of AKT1 are Associated with Risk Screening for Non-Alcoholic Fatty Liver Disease

单核苷酸多态性 脂肪肝 高甘油三酯血症 内科学 医学 胃肠病学 甘油三酯 体质指数 代谢综合征 内分泌学 肿瘤科 疾病 胆固醇 生物 基因型 遗传学 肥胖 基因
作者
Yajie Ding,Zongzhe Tang,Ru Zhang,Mengting Zhang,Qing Guan,Liuxin Zhang,Hongliang Wang,Yue Chen,Wei Zhang,Jie Wang
出处
期刊:Risk Management and Healthcare Policy [Dove Medical Press]
卷期号:Volume 16: 1365-1376
标识
DOI:10.2147/rmhp.s416592
摘要

Protein kinase B (PKB/AKT) has shown a high profile in the research of metabolic diseases. This research sought to determine whether the AKT1 gene's single nucleotide polymorphisms (SNPs) and the risk of developing non-alcoholic fatty liver disease (NAFLD) were related.Recruited in this case-control study were 2693 subjects, including 815 with NAFLD and 1878 without NAFLD. Three SNPs of AKT1 (rs2494732, rs2494752 and rs1130233) were genotyped. To examine the correlation between SNPs and NAFLD susceptibility, logistic regression was performed.After adjusting for sex, age, triglyceride and glucose, AKT1 rs2494732-C (all P < 0.05 in co-dominant model, dominant model and additive model) and rs2494752-G (P < 0.05 in co-dominant model) were linked to a lower risk of NAFLD. The combined effect of both SNPs on NAFLD risk was statistically significant, showing a dose dependence (Ptrend = 0.010). Sex, body mass index, hypertension, hyperglycemia, hypertriglyceridemia, high-density lipoprotein-cholesterol, alanine aminotransferase, and beneficial alleles were all significant predictors of NAFLD risk (all P < 0.05). The prediction model achieved good discrimination, with an area under the receiver operating characteristic curve of 0.779. The Hosmer-Lemeshow test suggested an inadequate calibration of the model (χ2 = 21.073, P = 0.007).AKT1 rs2494732 and rs2494752 may be related to Chinese NAFLD susceptibility. The prediction model combining both SNPs with clinical factors displays a strong ability to discriminate NAFLD patients. Both SNPs may be exploited to design new models for early screening of NAFLD high-risk population.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
彤光赫显发布了新的文献求助10
1秒前
1秒前
浔城游侠完成签到,获得积分10
2秒前
2秒前
失眠的板栗完成签到,获得积分10
3秒前
蝶步韶华发布了新的文献求助10
5秒前
Jay发布了新的文献求助10
5秒前
jbhb发布了新的文献求助10
7秒前
幸运星发布了新的文献求助10
10秒前
10秒前
10秒前
11秒前
13秒前
小王完成签到 ,获得积分10
16秒前
liuyunhao7207发布了新的文献求助10
16秒前
Nugget发布了新的文献求助10
16秒前
量子星尘发布了新的文献求助10
19秒前
蝶步韶华完成签到,获得积分10
19秒前
SciGPT应助wade采纳,获得10
21秒前
稳重水卉完成签到,获得积分10
24秒前
我是老大应助111采纳,获得10
25秒前
27秒前
情怀应助天真的高山采纳,获得10
28秒前
万能图书馆应助高木采纳,获得10
29秒前
积极以云完成签到,获得积分10
30秒前
30秒前
32秒前
CyrusSo524应助zzz采纳,获得10
33秒前
123完成签到,获得积分10
34秒前
兔子先生完成签到 ,获得积分10
35秒前
向日葵完成签到,获得积分10
37秒前
科研通AI5应助天天采纳,获得10
37秒前
彤光赫显完成签到,获得积分10
39秒前
long0809完成签到,获得积分10
42秒前
天天快乐应助段一帆采纳,获得10
44秒前
乐乐应助江江采纳,获得10
47秒前
48秒前
鹤鸣发布了新的文献求助30
48秒前
ding应助整齐小松鼠采纳,获得30
48秒前
wanci应助好吃采纳,获得10
49秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174