聚乳酸
降级(电信)
背景(考古学)
蛋白酶
化学
生物降解
可生物降解聚合物
塑料废料
化学工程
生化工程
材料科学
酶
环境科学
废物管理
计算机科学
有机化学
聚合物
工程类
生物
电信
古生物学
作者
Wenlong Pang,Ли Бин,Yufeng Wu,Shaonan Tian,Yu Zhang,Jun Yang
标识
DOI:10.1016/j.ijbiomac.2023.127496
摘要
With global enforcement of plastic bans and restrictions, the biodegradable plastic, e.g., polylactic acid (PLA), has been extensively employed as a primary substitute for traditional petroleum-based plastics. However, the growing problem associated with PLA waste accumulation is posing grand environmental challenges. In addition, although PLA has the degrading property under natural conditions, the degradation process takes too long and the degradation products cannot be recycled. In this context, enzymatic degradation of PLA arouses great attention in scientific communities. This study aims at selecting the most cost-effective protease from various enzymes and optimizing the enzymolysis conditions towards the degradation of PLA. We will demonstrate that under an optimal temperature of 45 °C, a pH vale of 11, and an enzyme concentration of 0.6 mg mL-1, the protease K would achieve a remarkable degradation efficiency (> 99 %) for PLA films within just 50 min. Finally, molecular dynamics (MD) simulation and molecular docking studies reveal the mechanism behind the protease-induced PLA degradation, providing a promising direction for waste treatment and resource utilization for future biodegradable plastics.
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