穹窿下器官
口渴
生物
内分泌学
内科学
视前正中核
平衡
前脑
分泌素
受体
神经科学
中枢神经系统
血管紧张素II
胰腺
血压
医学
生物化学
作者
Fengwei Zhang,Sarah O. K. Mak,Yuchu Liu,Ya Ke,Feng Rao,Wing‐Ho Yung,Li Zhang,Bkc Chow
出处
期刊:Current Biology
[Elsevier]
日期:2022-10-10
卷期号:32 (22): 4832-4841.e5
被引量:11
标识
DOI:10.1016/j.cub.2022.09.037
摘要
In mammals, thirst is strongly influenced by the subfornical organ (SFO), a forebrain structure that integrates circulating signals including osmotic pressure and sodium contents. Secretin (SCT), a classical gastrointestinal hormone, has been implicated as a humoral factor regulating body-fluid homeostasis. However, the neural mechanism of secretin in the central nervous system in managing thirst remains unclear. In this study, we report that the local ablation of SCT receptor (SCTR) in the SFO reduces water but not salt intake in dehydrated mice and this effect could not be rescued by exogenous SCT administration. Electrophysiology with single-cell RT-PCR indicates that SCT elicits inward currents in the SFO neuronal nitric oxide synthase (SFOnNOS) neurons via SCTR in the presence of glutamate receptor antagonists. We further show that the SCTR in the SFO permits the activation of SFOnNOS neurons under distinct thirst types. Projection-specific gene deletion of SCTR in SFO to the median preoptic nucleus (MnPO) pathway also reduces water intake in dehydrated animals. SCT signaling thus plays an indispensable role in driving thirst. These data not only expand the functional boundaries of SCTR but also provide insights into the central mechanisms of homeostatic regulation.
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