医学
临床试验
上瘾
药物开发
药物滥用
重症监护医学
药品
精神科
病理
作者
Md. Kamal Hossain,Majid Davidson,Erica Kypreos,Jack Feehan,Joshua Alexander Muir,Kulmira Nurgali,Vasso Apostolopoulos
出处
期刊:Vaccines
[MDPI AG]
日期:2022-10-22
卷期号:10 (11): 1778-1778
被引量:3
标识
DOI:10.3390/vaccines10111778
摘要
Substance use disorders (SUD) are a serious public health concern globally. Existing treatment platforms suffer from a lack of effectiveness. The development of immunotherapies against these substances of abuse for both prophylactic and therapeutic use has gained tremendous importance as an alternative and/or supplementary to existing therapies. Significant development has been made in this area over the last few decades. Herein, we highlight the vaccine and other biologics development strategies, preclinical, clinical updates along with challenges and future directions. Articles were searched in PubMed, ClinicalTrial.gov, and google electronic databases relevant to development, preclinical, clinical trials of nicotine, cocaine, methamphetamine, and opioid vaccines. Various new emerging vaccine development strategies for SUD were also identified through this search and discussed. A good number of vaccine candidates demonstrated promising results in preclinical and clinical phases and support the concept of developing a vaccine for SUD. However, there have been no ultimate success as yet, and there remain some challenges with a massive push to take more candidates to clinical trials for further evaluation to break the bottleneck.
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