PET Imaging of Nectin-4: A Promising Tool for Personalized/Precision Oncology

Summary In a recent study, the authors developed a nectin-4–targeting bicyclic peptide–based radiotracer, 68Ga-N188, for PET imaging of advanced urothelial cancer. Preclinical investigation and first-in-human study in 14 patients demonstrated excellent specificity and sensitivity of 68Ga-N188 in detecting metastases. These promising results support 68Ga-N188 as a companion diagnostic for future personalized cancer therapy. See related article by Duan et al., p. 3395