大麻酚
大麻
四氢大麻酚
大麻素
大麻的影响
屈大麻酚
药理学
医学
神经科学
精神科
生物
内科学
受体
出处
期刊:Neuron
[Elsevier]
日期:2023-01-01
标识
DOI:10.1016/j.neuron.2022.12.022
摘要
Summary
Δ9-tetrahydrocannabinol (THC) and its sibling, cannabidiol (CBD), are produced by the same Cannabis plant and have similar chemical structures but differ dramatically in their mechanisms of action and effects on brain functions. Both THC and CBD exhibit promising therapeutic properties; however, impairments and increased incidence of mental health diseases are associated with acute and chronic THC use, respectively, and significant side effects are associated with chronic use of high-dose CBD. This review covers recent molecular and preclinical discoveries concerning the distinct mechanisms of action and bioactivities of THC and CBD and their impact on human behavior and diseases. These discoveries provide a foundation for the development of cannabinoid-based therapeutics for multiple devastating diseases and to assure their safe use in the growing legal market of Cannabis-based products.
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