核酸检测
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病毒学
核酸
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
爆发
2019年冠状病毒病(COVID-19)
医学
生物
疾病
免疫学
传染病(医学专业)
病理
生物化学
作者
Huitao Huang,Dongling Long,Lin Yang,C. Dong,Wen-Qing Huang,M Zhang,Wan Liang,Hongna Gou,Tianlan Chen,Feifei Li
标识
DOI:10.1016/j.jcv.2024.105688
摘要
Respiratory pathogens, such as SARS-CoV-2 and influenza A/B, can cause severe illnesses in susceptible individuals. This research evaluated a novel digital microfluidic point-of-care testing platform designed to detect 23 pathogens, comparing its performance to conventional laboratory-based nucleic acid tests. The platform integrates nucleic acid extraction and amplification processes for rapid detection with only 2 minutes of hands-on time. Performance assays demonstrated that the platform has high sensitivity (87%-100%) and specificity (99%-100%) for the detection of the evaluated 3 viruses. Additionally, the platform can be adapted for the detection of other respiratory pathogens, aiding in the early diagnosis of respiratory diseases, identifying the source of an outbreak or epidemic, and curbing the spread of the disease.
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