炎症
生物
基因沉默
巨噬细胞
促炎细胞因子
信号转导
细胞生物学
基因表达调控
长非编码RNA
免疫学
基因
核糖核酸
遗传学
体外
作者
Avisankar Chini,Prarthana Guha,Arun K. Rishi,Monira Obaid,S. M. Nashir Udden,Subhrangsu S. Mandal
出处
期刊:Methods
[Elsevier]
日期:2024-05-03
卷期号:227: 1-16
被引量:1
标识
DOI:10.1016/j.ymeth.2024.05.001
摘要
Long noncoding RNAs (lncRNA) are emerging players in regulation of gene expression and cell signaling and their dysregulation has been implicated in a multitude of human diseases. Recent studies from our laboratory revealed that lncRNAs play critical roles in cytokine regulation, inflammation, and metabolism. We demonstrated that lncRNA HOTAIR, which is a well-known regulator of gene silencing, plays critical roles in modulation of cytokines and proinflammatory genes, and glucose metabolism in macrophages during inflammation. In addition, we recently discovered a series of novel lncRNAs that are closely associated with inflammation and macrophage activation. We termed these as long-noncoding inflammation associated RNAs (LinfRNAs). We are currently engaged in the functional characterization of these hLinfRNAs (human LinfRNAs) with a focus on their roles in inflammation, and we are investigating their potential implications in chronic inflammatory human diseases. Here, we have summarized experimental methods that have been utilized for the discovery and functional characterization of lncRNAs in inflammation and macrophage activation.
科研通智能强力驱动
Strongly Powered by AbleSci AI