Fenobam modulates distinct electrophysiological mechanisms for regulating excessive gamma oscillations in the striatum of dyskinetic rats

电生理学 纹状体 神经科学 生物 心理学 多巴胺
作者
Pengfei Wang,Weina Dai,Hongbin Liu,Han Liu,Yuming Xu
出处
期刊:Experimental Neurology [Elsevier BV]
卷期号:378: 114833-114833
标识
DOI:10.1016/j.expneurol.2024.114833
摘要

Gamma oscillations have been frequently observed in levodopa-induced dyskinesia (LID), manifest as broadband (60-120 Hz) and narrowband (80-110 Hz) gamma activity in cortico-striatal projection. We investigated the electrophysiological mechanisms and correlation of gamma oscillations with dyskinesia severity, while assessing the administration of fenobam, a selective metabotropic glutamate receptor 5 (mGluR5) antagonist, in regulating dyskinesia-associated gamma activity. We conducted simultaneous electrophysiological recordings in Striatum (Str) and primary motor cortex (M1), together with Abnormal Involuntary Movement Scale scoring (AIMs). Phase-amplitude coupling (PAC), power, coherence, and Granger causality analyses were conducted for electrophysiological data. The findings demonstrated increased beta oscillations with directionality from M1 to Str in parkinsonian state. During on-state dyskinesia, elevated broadband gamma activity was modulated by the phase of theta activity in Str, while M1 → Str gamma causality mediated narrowband gamma oscillations in Str. Striatal gamma power (both periodic and aperiodic power), periodic power, peak frequency, and PAC at 80 min (corresponding to the peak dyskinesia) after repeated levodopa injections across recording days (day 30, 33, 36, 39, and 42) increased progressively, correlating with total AIMs. Additionally, a time-dependent parabolic trend of PAC, peak frequency and gamma power was observed after levodopa injection on day 42 from 20 to 120 min, which also correlated with corresponding AIMs. Fenobam effectively alleviates dyskinesia, suppresses enhanced gamma oscillations in the M1-Str directionality, and reduces PAC in Str. The temporal characteristics of gamma oscillations provide parameters for classifying LID severity. Antagonizing striatal mGluR5, a promising therapeutic target for dyskinesia, exerts its effects by modulating gamma activity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李李完成签到,获得积分20
刚刚
爆米花应助卢敏明采纳,获得10
刚刚
gunt发布了新的文献求助30
1秒前
1秒前
CDKSEVEN发布了新的文献求助10
1秒前
caibaozi应助风清扬采纳,获得50
2秒前
贪玩小小发布了新的文献求助10
2秒前
汪汪发布了新的文献求助10
3秒前
3秒前
roclie完成签到,获得积分10
3秒前
文静的如娆完成签到,获得积分10
4秒前
5秒前
Yy完成签到,获得积分10
6秒前
7秒前
7秒前
7秒前
dengyan完成签到,获得积分10
8秒前
CodeCraft应助汪汪采纳,获得10
8秒前
我是老大应助刻苦的书竹采纳,获得10
9秒前
智慧爷爷发布了新的文献求助10
9秒前
酷波er应助lw777采纳,获得10
9秒前
岁月如歌发布了新的文献求助10
11秒前
bin完成签到,获得积分10
13秒前
13秒前
很好完成签到,获得积分10
14秒前
小郝已读博完成签到 ,获得积分10
14秒前
14秒前
Self-made完成签到,获得积分10
14秒前
15秒前
16秒前
17秒前
岁月如歌完成签到,获得积分10
18秒前
19秒前
joey完成签到,获得积分10
20秒前
wei完成签到 ,获得积分10
21秒前
miaojuly发布了新的文献求助10
22秒前
22秒前
研友_LXjjOZ发布了新的文献求助150
22秒前
23秒前
24秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035