黄曲霉毒素
氧化应激
过氧化氢酶
丙二醛
绿原酸
谷胱甘肽
炎症
抗氧化剂
药理学
化学
医学
生物化学
免疫学
食品科学
酶
作者
Kang Cheng,Jingyi Niu,Jinyan Zhang,Yining Qiao,Guorun Dong,Rui Guo,Xiaotong Zheng,Zhihua Song,Jin Huang,JinRong Wang,Yong Zhang
出处
期刊:Toxicon
[Elsevier]
日期:2023-06-03
卷期号:231: 107177-107177
被引量:7
标识
DOI:10.1016/j.toxicon.2023.107177
摘要
Aflatoxin B1 (AFB1) is widely distributed in crops and feeds, and ingestion of AFB1-contaminated crops is harmful to human/animal health. This study was designed to investigate hepatoprotective effects of chlorogenic acid (CGA), due to its excellent antioxidant and anti-inflammatory activities, on mice exposed to AFB1. Male Kunming mice were orally fed with CGA prior to daily AFB1 exposure for 18 consecutive days. The results showed that CGA treatment reduced the serum activity of aspartate aminotransferase, hepatic malondialdehyde content and pro-inflammatory cytokines synthesis, prevented histopathological changes of the liver, increased hepatic glutathione level, catalase activity and IL10 mRNA expression in mice subjected to AFB1. Taken together, CGA exerted the protective effect on AFB1-induced hepatic damage by modulating redox status and inflammation, suggesting that CGA may be a candidate compound for the treatment of aflatoxicosis.
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