Research progress on the prevention of tumor by fungal polysaccharides

多糖 癌变 生物利用度 癌症 生物 生物技术 生物信息学 癌症研究 医学 生物化学 遗传学
作者
Wenbin Yu,Yufei Zhang,Lihua Yao,Jiahua Peng,Yayi Tu,Bin He
出处
期刊:Trends in Food Science and Technology [Elsevier]
卷期号:147: 104422-104422 被引量:6
标识
DOI:10.1016/j.tifs.2024.104422
摘要

Tumor has been considered as a serious public health concern and a prominent contributing factor to the prevalence of cancer and global mortality rates. Extensive epidemiological investigations have consistently established a correlation between a high consumption of fungal polysaccharides-rich foods, and a decreased risk of tumorigenesis. Although numerous studies have exemplified the anti-tumor properties exhibited by fungal polysaccharides compounds, a comprehensive and systematic evaluation of their efficacy and mechanisms in treating tumors remains notably limited. This article reviews clinical trials and experimental studies regarding the anti-tumor effects and respective molecular mechanisms of common dietary fungal polysaccharides from 2011 to 2023 available in PubMed. Based on published investigations, dietary fungal polysaccharides exhibit various mechanisms of action that contribute to their anti-tumor potentials, including the effects of antioxidation, anti-angiogenesis, apoptosis induction, cell cycle regulation and immunomodulation. This comprehensive review also highlights recent advancements in understanding the bioavailability of fungal polysaccharides, as well as the essential role played by gut microbes in their metabolism. However, further research is needed to enhance our understanding of the intricate mechanisms underlying fungal polysaccharides' bioavailability. Such studies will undoubtedly facilitate the development of precise dietary interventions for preventing and treating tumors.
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