Oral fusidic acid for the treatment of mild‐to‐moderate hidradenitis suppurativa

化脓性汗腺炎 医学 夫西地酸 皮肤病科 皮肤科药物 内科学 抗生素 微生物学 金黄色葡萄球菌 疾病 细菌 遗传学 生物
作者
A. Wiala,Sophie M. Daschl,Theresa Stockinger,Klemens Rappersberger,Christian Posch
出处
期刊:International Journal of Dermatology [Wiley]
标识
DOI:10.1111/ijd.17115
摘要

Abstract Background Hidradenitis suppurativa (HS) is a debilitating inflammatory skin disease. Tetracyclines are one of the few therapeutic options recommended for mild‐to‐moderate disease. This study aimed to investigate the efficacy of systemic fusidic acid's (FA) effectiveness in treating HS. Methods This retrospective study analyzed 55 FA therapy cycles (TC, average weekly dose: 6409 mg; range: 5250–9800 mg; 2–12 weeks) in 49 patients. The outcome was evaluated using the Physician's Global Assessment (PGA) scale. Therapy response was defined as any reduction of inflammatory activity without the occurrence of flares. We also characterized adverse events and investigated predictors for treatment success. Results were compared to a matched control group receiving doxycycline. Results FA treatment (55 treatment cycles (TC); male: 45.5%; female: 54.5%) showed an overall response rate of 70.9% (39 TC). No worsening was observed. Significantly higher response rates were observed in females (83.3%, P = 0.026) and Hurley I (90.9%, P = 0.008). After multivariate adjustment, higher response rates were associated with the Hurley grade ( P = 0.046) but not with gender ( P = 0.0174). Adverse reactions (21.8% gastrointestinal symptoms) occurred in 27.3% (15 TC) and 46.7% within the first 4 weeks. Similar results were observed in the doxycycline control group (overall response rate: 76.4%). Conclusion Oral FA is safe and improves symptoms in most patients. HS patients could benefit from oral FA treatment, especially in case of contraindications or resistance to tetracyclines.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
忆茶戏发布了新的文献求助10
1秒前
酷波er应助幸运星采纳,获得10
3秒前
华仔应助张雯思采纳,获得10
3秒前
CipherSage应助张雯思采纳,获得30
3秒前
星辰大海应助张雯思采纳,获得10
3秒前
搜集达人应助张雯思采纳,获得10
3秒前
3秒前
田様应助Cl1audia采纳,获得10
3秒前
123发布了新的文献求助10
4秒前
4秒前
搜集达人应助Ma采纳,获得10
4秒前
大模型应助孟欣玥采纳,获得10
4秒前
木可发布了新的文献求助10
5秒前
泊頔完成签到,获得积分10
7秒前
lrq发布了新的文献求助10
8秒前
8秒前
wwl关闭了wwl文献求助
10秒前
mr_chxb82发布了新的文献求助10
10秒前
阿智完成签到,获得积分10
10秒前
大写的LV完成签到 ,获得积分10
11秒前
麦子发布了新的文献求助10
12秒前
852应助wbh采纳,获得10
13秒前
17秒前
lzx发布了新的文献求助10
18秒前
王彩香发布了新的文献求助10
19秒前
五六七发布了新的文献求助150
20秒前
20秒前
mr_chxb82完成签到,获得积分10
20秒前
量子星尘发布了新的文献求助10
21秒前
小二郎应助麦子采纳,获得10
22秒前
清脆凡阳完成签到 ,获得积分10
22秒前
香蕉觅云应助小晓采纳,获得10
23秒前
科研通AI2S应助wwl采纳,获得10
25秒前
28秒前
眉间尺完成签到,获得积分10
30秒前
DC发布了新的文献求助10
31秒前
我们发布了新的文献求助10
33秒前
贪玩的野狍子完成签到,获得积分20
34秒前
、、、完成签到,获得积分10
39秒前
lrq完成签到,获得积分10
41秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989444
求助须知:如何正确求助?哪些是违规求助? 3531531
关于积分的说明 11254250
捐赠科研通 3270191
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174