医学
骨关节炎
内科学
队列
体质指数
炎症
脂肪因子
置信区间
队列研究
混淆
生物标志物
前瞻性队列研究
胰岛素抵抗
肥胖
病理
生物
替代医学
生物化学
作者
Timothy E. McAlindon,Jennifer L. Hunnicutt,Mary B. Roberts,Ida K Haugen,L.F. Schaefer,Jeffrey B. Driban,Bing Lü,J. Duryea,Stacy E. Smith,Sarah L. Booth,G. Petty,Alexander Mathiessen,Li Zeng,Charles B. Eaton
标识
DOI:10.1016/j.joca.2023.10.011
摘要
Erosive hand osteoarthritis (eHOA) is a subtype of hand osteoarthritis (OA) that develops in finger joints with pre-existing OA and is differentiated by clinical characteristics (hand pain/disability, inflammation, and erosions) that suggest inflammatory or metabolic processes.This was a longitudinal nested case-cohort design among Osteoarthritis Initiative participants who had hand radiographs at baseline and 48-months, and biospecimens collected at baseline. We classified incident radiographic eHOA in individuals with ≥1 joint with Kellgren-Lawrence ≥2 and a central erosion present at 48-months but not at baseline. We used a random representative sample (n = 1282) for comparison. We measured serum biomarkers of inflammation, insulin resistance and dysglycemia, and adipokines using immunoassays and enzymatic colorimetric procedures, blinded to case status.Eighty-six participants developed incident radiographic eHOA. In the multivariate analyses adjusted for age, gender, race, smoking, and body mass index, and after adjustment for multiple analyses, incident radiographic eHOA was associated with elevated levels of interleukin-7 (risk ratio (RR) per SD = 1.30 [95% confidence interval (CI) 1.09, 1.55] p trend 0.01).This exploratory study suggests an association of elevated interleukin-7, an inflammatory cytokine, with incident eHOA, while other cytokines or biomarkers of metabolic inflammation were not associated. Interleukin-7 may mediate inflammation and tissue damage in susceptible osteoarthritic finger joints and participate in erosive progression.
科研通智能强力驱动
Strongly Powered by AbleSci AI