内吞作用
材料科学
光热治疗
血管生成
肿瘤微环境
化学
癌症研究
纳米技术
细胞生物学
肿瘤细胞
生物
细胞
生物化学
作者
Tianyu Wang,X. L. Zhu,Hao‐Ran Jia,Ya‐Xuan Zhu,Yong‐Xi Zhou,Yanhong Li,Cheng‐Zhe Gao,Guang‐Yu Pan,Fu‐Gen Wu
出处
期刊:Small
[Wiley]
日期:2024-02-19
卷期号:20 (26)
被引量:1
标识
DOI:10.1002/smll.202308861
摘要
The anabolism of tumor cells can not only support their proliferation, but also endow them with a steady influx of exogenous nutrients. Therefore, consuming metabolic substrates or limiting access to energy supply can be an effective strategy to impede tumor growth. Herein, a novel treatment paradigm of starving-like therapy-triple energy-depleting therapy-is illustrated by glucose oxidase (GOx)/dc-IR825/sorafenib liposomes (termed GISLs), and such a triple energy-depleting therapy exhibits a more effective tumor-killing effect than conventional starvation therapy that only cuts off one of the energy supplies. Specifically, GOx can continuously consume glucose and generate toxic H
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