睾丸炎
炎症
医学
免疫学
自身免疫
发病机制
脂多糖
免疫系统
病理
作者
Chunmei Ma,Jiajia Huang,Yuying Jiang,Lu Liu,Na Wang,Shaoqiong Huang,Honghui Li,Xiangyu Zhang,Shuang Wen,Bingwei Wang,Shuo Yang
标识
DOI:10.1038/s44321-023-00016-8
摘要
Abstract Inflammation in the testes induced by infection and autoimmunity contributes significantly to male infertility, a public health issue. Current therapies using antibiotics and broad-spectrum anti-inflammatory drugs are ineffective against non-bacterial orchitis and induce side effects. This highlights the need to explore the pathogenesis of orchitis and develop alternative therapeutic strategies. In this study, we demonstrated that Gasdermin D (GSDMD) was activated in the testes during uropathogenic Escherichia coli (UPEC)-induced acute orchitis, and that GSDMD in macrophages induced inflammation and affected spermatogenesis during acute and chronic orchitis. In testicular macrophages, GSDMD promoted inflammation and antigen presentation, thereby enhancing the T-cell response after orchitis. Furthermore, the pharmacological inhibition of GSDMD alleviated the symptoms of UPEC-induced acute orchitis. Collectively, these findings provide the first demonstration of GSDMD’s role in driving orchitis and suggest that GSDMD may be a potential therapeutic target for treating orchitis.
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