丝素
涂层
镁
腐蚀
螯合作用
金属
溶剂
水溶液中的金属离子
材料科学
化学工程
镁合金
丝绸
无机化学
化学
高分子化学
冶金
有机化学
纳米技术
复合材料
工程类
作者
Haotong Li,Tingji Ma,Jingwu Zhang,Zhinan Mao,Hongxing Liang,Yuehua Sun,Hang Zhao,Yutao Ding,Xinru Cao,Zhihan Zhang,Wenjing Zhao,Liang Wu,Kang Yang
标识
DOI:10.1016/j.cej.2024.149905
摘要
The development of biofunctional coating is vital for the clinical application of implants. A persistent challenge with magnesium alloys implants, which are inherently prone to rapid degradation, is the simultaneously enhancement of corrosion resistance and bioactivity. This study introduces a novel protein coating for magnesium alloys, incorporating calcium and strontium ions with silk fibroin. By utilizing the microcrystal nucleation facilitated by a binary solvent system, the β-sheet content is significantly increased to 45.4 % in silk fibroin. The increased β-sheet bolsters the "labyrinth effect" at the nanoscale, resulting in a substantial improvement in corrosion resistance. This is evidenced by a three-order-of-magnitude reduction in the corrosion current density (Icorr) to 3.65 × 10−7 A cm−2, compared to that of the uncoated alloys. The meticulous doping of Ca2+ and Sr2+ ions ensures stable chelation with amorphous segments of silk fibroin. The controlled release activates the Wnt signaling pathway, boosting osteogenic activity. Such silk fibroin coating system, prepared through a straightforward method, enables a concurrent enhancement of both corrosion resistance and osteogenic potential in biomedical magnesium alloys.
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