Targeting Dickkopf-1 in heart disease

We eagerly read the study authored by Xu [ [1] Xu P. Cao Y. Zhang S. et al. The predictive value of serum Dickkopf-1, Dickkopf-3 level to coronary artery disease and acute coronary syndrome[J]. Int. J. Cardiol. 2024; 403: 131887 Google Scholar ] and his colleagues, 'The predictive value of serum Dickkopf-1, Dickkopf-3 level to coronary artery disease and acute coronary syndrome'. They demonstrated that the serum levels of Dickkopf-1 were significantly higher in the CHD group compared to the control group. This suggest that Dickkopf-1 may play a critical role in the pathogenesis of heart disease.