狨猴
紫苏蓟马
前列腺癌
前列腺
谷氨酸羧肽酶Ⅱ
免疫组织化学
生物
生物标志物
癌症研究
医学
免疫学
内科学
癌症
遗传学
古生物学
作者
Diane E. Peters,Michael Brownlee,Donna Layne‐Colon,Barbara S. Slusher
摘要
Abstract Background Prostate‐specific membrane antigen (PSMA) is a biomarker and therapeutic target of high relevance in prostate cancer. Although upregulated PSMA expression is a well‐documented feature of prostatic neoplasia in both humans and canids, to date humans are the only species known to express PSMA basally in the prostate. Thus, traditional laboratory animal species have limited utility for studying PSMA biology in the prostate or for predicting efficacy or toxicity of PSMA‐targeted agents. Methods PSMA expression in human, macaque, and marmoset prostates was determined by immunohistochemistry, employing an antibody with validated cross‐species reactivity in a PSMA‐positive control tissue; kidney. Results We newly discover that the common marmoset endogenously expresses PSMA in non‐diseased prostate, similar to humans, and thus may be a valuable preclinical model for researchers studying PSMA.
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