Three-dimensional Ultrashort Echotime Magnetic Resonance Imaging for Combined Morphologic and Ventilation Imaging in Pediatric Patients With Pulmonary Disease

医学 肺不张 磁共振成像 放射科 无症状的 空气滞留 通风(建筑) 肺隔离症 病理 肺功能测试 内科学 机械工程 工程类
作者
Simon Veldhoen,Julius F. Heidenreich,Corona Metz,Bernhard Petritsch,Thomas Benkert,Helge Hebestreit,Thorsten Alexander Bley,Herbert Köstler,Andreas Max Weng
出处
期刊:Journal of Thoracic Imaging [Lippincott Williams & Wilkins]
卷期号:36 (1): 43-51 被引量:14
标识
DOI:10.1097/rti.0000000000000537
摘要

Purpose: Ultrashort echotime (UTE) sequences aim to improve the signal yield in pulmonary magnetic resonance imaging (MRI). We demonstrate the initial results of spiral 3-dimensional (3D) UTE-MRI for combined morphologic and functional imaging in pediatric patients. Methods: Seven pediatric patients with pulmonary abnormalities were included in this observational, prospective, single-center study, with the patients having the following conditions: cystic fibrosis (CF) with middle lobe atelectasis, CF with allergic bronchopulmonary aspergillosis, primary ciliary dyskinesia, air trapping, congenital lobar overinflation, congenital pulmonary airway malformation, and pulmonary hamartoma. Patients were scanned during breath-hold in 5 breathing states on a 3-Tesla system using a prototypical 3D stack-of-spirals UTE sequence. Ventilation maps and signal intensity maps were calculated. Morphologic images, ventilation-weighted maps, and signal intensity maps of the lungs of each patient were assessed intraindividually and compared with reference examinations. Results: With a scan time of ∼15 seconds per breathing state, 3D UTE-MRI allowed for sufficient imaging of both “plus” pathologies (atelectasis, inflammatory consolidation, and pulmonary hamartoma) and “minus” pathologies (congenital lobar overinflation, congenital pulmonary airway malformation, and air trapping). Color-coded maps of normalized signal intensity and ventilation increased diagnostic confidence, particularly with regard to “minus” pathologies. UTE-MRI detected new atelectasis in an asymptomatic CF patient, allowing for rapid and successful therapy initiation, and it was able to reproduce atelectasis and hamartoma known from multidetector computed tomography and to monitor a patient with allergic bronchopulmonary aspergillosis. Conclusion: 3D UTE-MRI using a stack-of-spirals trajectory enables combined morphologic and functional imaging of the lungs within ~115 second acquisition time and might be suitable for monitoring a wide spectrum of pulmonary diseases.
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