In-situ synthesis of ultrasmall Au nanoparticles on bimetallic metal-organic framework with enhanced electrochemical activity for estrone sensing

In this work, ultrasmall Au nanoparticles decorated bimetallic metal-organic framework (US Au NPs@AuZn-MOF) hybrids were facilely prepared by a sequential ion exchange and in-situ chemical reduction strategy. Numerous of Au nanoparticles with size less than 5 nm was homogeneously dispersed on the surface of the whole bimetallic AuZn-MOF polyhedrons. The integration of ultrasmall Au nanoparticles greatly enhanced the electron transfer capacity and electrochemical active surface area of the metal-organic framework host. Compared with the pristine Zn-MOF, bimetallic AuZn-MOF, the as-synthesized US Au NPs@AuZn-MOF hybrids exhibited remarkably promoted electrochemical activity toward the oxidation and sensing of endocrine-disrupting chemical (EDC) estrone. As a result, a highly sensitive electrochemical sensing platform was developed for the detection of estrone in the range of 0.05 μM–5 μM with limit of detection of 12.3 nM (S/N = 3) and sensitivity of 101.3 μA −1 μM −1 cm −2 . Considering the structural diversity of MOFs and superior property of ultrasmall Au nanoparticles, the strategy proposed here may open a new avenue for the design and synthesis of other high-activity nanomaterials for electrochemical sensing or other challenging fields. • Au nanoparticles was deposited on MOFs with ultrasmall size and ultrahigh dispersion degree. • The ultrasmall Au nanoparticles greatly boosted the electrochemical activity of MOFs. • A novel and efficient estrone electrochemical sensing platform was successfully developed. • Simple and novel strategy was present to improve the electrochemical sensing performance of MOFs.