Interactions of mono spermine porphyrin derivative with DNAs

Abstract In this work, we have characterized the interactions of monospermine porphyrin derivative with calf thymus DNA (ct‐DNA) and poly (dG‐dC) 2 in both B and Z conformation. By several spectroscopic techniques (UV–vis, electronic circular dichroism and resonance light scattering), the binding modes of monospermine porphyrin derivative with different DNA sequences have been elucidated. In the presence of ct‐DNA, the porphyrin binds along the external double helix as well as in the presence of B conformation of poly (dG‐dC) 2 . Whilst when the Z form of the poly (dG‐dC) 2 is induced, a slight intercalation of the porphyrin between the basis has been detected.