Epidemiology and disease burden of non-alcoholic steatohepatitis in greater China: a systematic review

医学 脂肪性肝炎 流行病学 脂肪肝 公共卫生 人口 环境卫生 疾病 疾病负担 内科学 病理
作者
Huimin Zou,Ying Ge,Qing Lei,Carolina Oi Lam Ung,Zhen Ruan,Yunfeng Lai,Dongning Yao,Hao Hu
出处
期刊:Hepatology International [Springer Nature]
卷期号:16 (1): 27-37 被引量:10
标识
DOI:10.1007/s12072-021-10286-4
摘要

Non-alcoholic steatohepatitis (NASH) is a progression of non-alcoholic fatty liver disease. The increasing burden of NASH has become a major concern of public health in greater China. This study aimed to characterize the epidemiology, disease burden, and treatment of NASH in greater China to better inform national disease management and delivery of health services.We conducted a systematic review searching four English databases (Web of Science, PubMed, Medline, and Cochrane Central) and three Chinese databases (CNKI, Wanfang, and VIP). We identified articles published from database inception to October 10, 2020 which reported NASH epidemiology, disease burden, and/or intervention in Chinese adults.Of 44,115 articles retrieved, 33 were eligible for inclusion. Overall prevalence of NASH ranged from 2.4 to 6.1% in greater China, with a more substantial burden among males, the aged, and those in Hong Kong and Taiwan. Most NASH patients suffered from several comorbidities, including obesity, diabetes, and cardiovascular conditions. PNPLA3 rs738409 G allele and haptoglobin 2-2 genotype drove the fibrosis progression in NASH. Increasingly prevalent cases of cirrhosis and hepatocellular carcinoma caused a higher NASH-related mortality. Compared with normal population, NASH patients experienced markedly poorer quality of life and heavier costs.This is the first comprehensive overview of NASH among Chinese population that revealed an overwhelming impact of social and healthcare burden associated with the condition. Further high-quality studies are needed to improve the understanding and management of NASH in greater China.
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