Complicated and uncomplicated S. aureus bacteraemia: an international Delphi survey among infectious diseases experts on definitions and treatment

医学 心内膜炎 重症监护医学 利福平 德尔菲法 抗生素 内科学 抗生素治疗 金黄色葡萄球菌 外科 病理 肺结核 统计 遗传学 数学 细菌 微生物学 生物
作者
Stefan Hagel,Christina Forstner,Richard Schumann,Mathias W. Pletz,Sebastian Weis
出处
期刊:Clinical Microbiology and Infection [Elsevier]
卷期号:28 (7): 1026.e7-1026.e11 被引量:15
标识
DOI:10.1016/j.cmi.2022.03.025
摘要

Classification of Staphylococcus aureus bacteraemia (SAB) as 'complicated' or 'uncomplicated' and management of both is based on low-quality evidence. The aim of the study was to determine the degree of agreement among infectious diseases physician experts in the management of patients with SAB.A stepwise RAND-modified Delphi procedure with two questionnaire rounds was performed. Four aspects of management in 22 clinical scenarios were addressed: (a) classification of SAB episodes; (b) value of combination therapy; and (c) timing of and (d) preferred antibiotics for oral stepdown therapy.Out of 90 approached experts, 33 (36.7%) from 14 different countries and 5 continents consented to participate. The experts considered any of the discussed implanted foreign material (with no evidence of infection), except for coronary artery stents, as relevant to the classification of a complicated SAB episode. Concerning antibiotic combination therapy, the experts strongly agreed that combination therapy with rifampicin is only relevant in patients with prosthetic valve endocarditis and prosthetic joint infection. The experts considered an oral stepdown therapy in patients with an uncomplicated SAB within 14 days and only thereafter in patients with a complicated SAB episode, but never in patients with prosthetic valve endocarditis. No single antibiotic of choice for oral stepdown therapy could be identified, neither for infections with methicillin-resistant S. aureus nor methicillin-susceptible S. aureus.The Delphi survey can help physicians in their day-to-day decision-making process, and it reveals open questions that must be investigated by further studies.
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