The impact of nanodroplets has received increasing attention due to their wide applications in nanotechnologies. A phase diagram containing four impact regimes is constructed for the impact of nanodroplets on nanopillared surfaces. Several significant differences in the impact regimes are distinguished between the nanoscale and macroscale. The wetting transition at the nanoscale does not follow the macroscale mechanisms and, hence, a new model is proposed to understand the wetting transition mechanism at the nanoscale.