Is Hypofractionation a Good Idea in Radiotherapy for Locally Advanced NSCLC?

Conventional or standard radiotherapy (2 Gy/d, 5 d/wk, up to 60 Gy) as used in locally advanced NSCLC (LA-NSCLC) relies on differential cell kill and regeneration between normal tissues and tumors, which has been firmly established across tumor sites. In LA-NSCLC, the Radiation Therapy Oncology Group 06/17 trial confirmed that 60 Gy standard fractionation remains the standard of care in concurrent chemoradiotherapy.1