Influenza-existing drugs and treatment prospects

大流行 病毒 神经氨酸酶 疾病 药品 人口 病毒学 医学 甲型流感病毒 药物开发 重症监护医学 药理学 传染病(医学专业) 2019年冠状病毒病(COVID-19) 内科学 环境卫生
作者
Avishak Sarker,Zichen Gu,Lu Mao,Yongzhuang Ge,Duoduo Hou,Jieyu Fang,Zhanyong Wei,Zhenya Wang
出处
期刊:European journal of medicinal chemistry [Elsevier]
卷期号:232: 114189-114189 被引量:38
标识
DOI:10.1016/j.ejmech.2022.114189
摘要

Influenza is a century-old disease that continues to baffle humans by its frequently changing nature, seasonal epidemics, and occasional pandemics. Approximately 9% of the world's population is infected by the influenza virus annually. The emergence of novel strains because of rapid mutations as well as interspecies disease contamination, limits the efficiency of strain-specific vaccines. Anti-influenza drugs such as neuraminidase inhibitors, M2 ion channel inhibitors, etc. have become the first line of defense in prophylaxis and early containment of the disease. But the growing drug resistance due to drug-induced selective pressure has also limited the efficacy of those drugs. Because we can't predict the next strain types, their virulence, or the severity of the next epidemic/pandemic caused by influenza virus, we ought to gear up for the development of novel anti-influenza drugs with a broad spectrum of reactivity against all strains and subtypes, better bioavailability, easier administrative pathways, and lesser adverse effects. Various new compounds with each having significantly different target molecules and pharmacologic activity have shown potential against influenza virus strains in laboratory situations as well as clinical trials. We should also consider combination therapy to boost the efficacy of existing drugs. This review is aiming to succinctly document the recent signs of progress regarding anti-influenza drugs both in the market and under investigation.
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