劈理(地质)
化学
区域选择性
亲核细胞
功能群
羧酸
键裂
分子
组合化学
有机化学
催化作用
断裂(地质)
工程类
岩土工程
聚合物
作者
Chengyihan Gu,Shuaishuai Wang,Qingran Zhang,Jin Xie
摘要
In this communication, we report a photocatalyzed amidation strategy from carboxylic acids and tertiary amines through C-N bond cleavage. A wide scope of structurally diverse carboxylic acids participate smoothly in the reaction, providing the desired tertiary amides with moderate-to-good yields (34 examples, up to 93% yield). This amidation strategy provides an alternative way to address the regioselectivity between nucleophilic functional groups, thus complementing the functional group compatibility of classical amidation protocols. Its synthetic robustness is also proved by the late-stage modification of several complex molecules and gram-scale applications.
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