植物乳杆菌
肠道菌群
蛋白激酶B
高磷酸化
PI3K/AKT/mTOR通路
医学
肠-脑轴
葛兰素史克-3
生物
免疫学
信号转导
磷酸化
细胞生物学
细菌
遗传学
乳酸
作者
Xinping Song,Zijian Zhao,Yujuan Zhao,Zhiguo Wang,Chao Wang,Ge Yang,Shengyu Li
标识
DOI:10.1080/1028415x.2021.1991556
摘要
Probiotic intervention has beneficial effects on host brain function and behavior via regulating microbiota-gut-brain axis; however, the underlying mechanism is not yet understood. Herein, we investigated that the effects of Lactobacillus plantarum DP189 (DP189) administration in preventing cognitive dysfunction and pathology of Alzheimer's disease (AD) in D-galactose (D-gal) and AlCl3-induced AD model mice. After L. plantarum DP189 intervention for 10 weeks, we assessed cognitive behavior, neurotransmitter expression, histological changes, microbial communities, and the mechanisms underlying the disease in AD model mice. The results showed that L. plantarum DP189 intervention prevented cognitive dysfunction by behavioral test. Increased levels of serotonin, dopamine, and gamma-aminobutyric acid positively affected the pathological processes by ameliorating neuronal damage, beta-amyloid deposition, and tau pathology. L. plantarum DP189 intervention simultaneously modulated the gut microbial communities to alleviate gut dysbiosis. Moreover, L. plantarum DP189 inhibited tau hyperphosphorylation by regulating the PI3 K/Akt/GSK-3β pathway. These findings indicated that L. plantarum DP189 intervention is a promising therapeutic strategy to prevent the onset and development of AD.
科研通智能强力驱动
Strongly Powered by AbleSci AI