褪黑素
免疫系统
癌症
放射治疗
癌症研究
医学
癌细胞
免疫疗法
炎症
免疫学
毒性
药理学
生物
内科学
作者
Masoud Moslehi,Reza Moazamiyanfar,Mohammad Sedigh Dakkali,Sepideh Rezaei,Nima Rastegar‐Pouyani,Emad Jafarzadeh,Kave Mouludi,Ehsan Khodamoradi,Shahram Taeb,Masoud Najafi
标识
DOI:10.1016/j.intimp.2022.108890
摘要
Immune system interactions within the tumour have a key role in the resistance or sensitization of cancer cells to anti-cancer agents. On the other hand, activation of the immune system in normal tissues following chemotherapy or radiotherapy is associated with acute and late effects such as inflammation and fibrosis. Some immune responses can reduce the efficiency of anti-cancer therapy and also promote normal tissue toxicity. Modulation of immune responses can boost the efficiency of anti-tumour therapy and alleviate normal tissue toxicity. Melatonin is a natural body agent that has shown promising results for modulating tumour response to therapy and also alleviating normal tissue toxicity. This review tries to focus on the immunomodulatory actions of melatonin in both tumour and normal tissues. We will explain how anti-cancer drugs may cause toxicity for normal tissues and how tumours can adapt themselves to ionizing radiation and anti-cancer drugs. Then, cellular and molecular mechanisms of immunoregulatory effects of melatonin alone or combined with other anti-cancer agents will be discussed.
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