Galectin‐3 is overexpressed in advanced cirrhosis and predicts post‐liver transplant infectious complications

医学 肝硬化 内科学 胃肠病学 比例危险模型 肝移植 危险系数 酒精性肝病 半乳糖凝集素-3 纤维化 肝病 移植 免疫学 置信区间
作者
Eduardo Cervantes-Álvarez,Nathaly Limon‐de la Rosa,Mario Vilatobá,Carlos Pérez‐Monter,S. Hurtado-Gómez,Cynthia Martinez‐Cabrera,Josepmaría Argemi,Elisa Alatorre‐Arenas,Susana Yarza‐Regalado,Farid Tejeda‐Dominguez,María José Lizardo-Thiebaud,Osvely Méndez-Guerrero,Armando Gamboa‐Domínguez,Carlos A. Aguilar‐Salinas,Christene A. Huang,David Kershenobich,R Bataller,Aldo Torre,Nalu Navarro–Álvarez
出处
期刊:Liver International [Wiley]
卷期号:42 (10): 2260-2273 被引量:13
标识
DOI:10.1111/liv.15326
摘要

Abstract Background & Aims Patients with advanced cirrhosis often have immune dysfunction and are more susceptible to infections. Galectin‐3 is a β‐galactoside‐binding lectin implicated in inflammation, immune regulation and liver fibrosis. We aim to investigate galectin‐3 expression in advanced cirrhosis and its ability to predict post‐transplant infectious complications. Methods We collected sera and liver samples from 129 cirrhotic patients at the time of liver transplantation and from an external cohort of 37 patients with alcoholic liver disease including alcoholic hepatitis (AH) at the time of diagnosis. Galectin‐3 was assessed by ELISA, real‐time PCR, immunohistochemistry and RNA‐seq. Receiver operating characteristic curves and Cox proportional‐hazards regression analysis were performed to assess the predictive power of galectin‐3 for disease severity and post‐transplant infections. Results Increased galectin‐3 levels were found in advanced cirrhosis. Galectin‐3 significantly correlated with disease severity parameters and inflammatory markers. Galectin‐3 had significant discriminating power for compensated and advanced cirrhosis (AUC = 0.78/0.84, circulating/liver galectin‐3; p < .01), and was even higher to discriminate severe AH (AUC = 0.95, p < .0001). Cox Proportional‐hazard model showed that galectin‐3, MELD‐Na and the presence of SIRS predict the development of post‐transplant infectious complications. Patients with circulating galectin‐3 (>16.58 ng/ml) were at 2.19‐fold 95% CI (1.12–4.29) increased risk, but when combined with MELD‐Na > 20.0 and SIRS, the risk to develop post‐transplant infectious complications, increased to 4.60, 95% CI (2.38–8.90). Conclusion Galectin‐3 is a novel biological marker of active inflammation and disease severity that could be clinically useful alone or in combination with other scores to discriminate advanced cirrhosis and predict post‐transplant infectious complications.
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